Development of human alveolar epithelial cell models to study distal lung biology and disease
Summary: Many acute and chronic diseases affect the distal lung alveoli.Alveolar epithelial cell (AEC) lines are needed to better model these diseases.We used de-identified human remnant transplant lungs to develop a method to establish AEC lines.The lines grow well in 2-dimensional (2D) culture as epithelial monolayers expressing lung progenitor m